Transmembrane protein

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Definition

Transmembrane proteins (acronym TM) (also called integral polytopic proteins) are a particular kind of integral membrane protein attached to the lipid bilayer in a biological membrane.

Transmembrane proteins are attached across both the two layers (the inner leaflet and the outer leaflet) of the lipid bilayer. In this, they differ from the integral monotopic proteins, which are permanently attached to the membrane from only one side.

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