Transmembrane protein

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Transmembrane proteins (acronym TM) (also called integral polytopic proteins) are a particular kind of defining ingredient::integral membrane protein attached to the defining ingredient::lipid bilayer in a defining ingredient::biological membrane.

Transmembrane proteins are attached across both the two layers (the inner leaflet and the outer leaflet) of the lipid bilayer. In this, they differ from the integral monotopic proteins, which are permanently attached to the membrane from only one side.